Effectiveness of renal denervation for treatment of resistant hypertension: an evidence-based case report.

نویسندگان

  • Minarma Siagian
  • Aldo Ferly
  • Arinna Irianti
  • Arky Kurniati
  • Florence Low
  • Ras A Riza
چکیده

AIM To determine whether the renal sympathetic--nerve ablation method is more effective compared to multiple anti--hypertensive drug among patients with resistant hypertension. METHODS a search was conducted on PubMed. The selection of title and abstract was conducted using inclusion and exclusion criteria, which led to five relevant articles. The selected studies were critically appraised for its validity, importance and applicability. RESULTS one of studies showed that renal denervation is not effectively reduced blood pressure in patients with resistant hypertension; nevertheless other studies showed significant results. CONCLUSION literature with strongest evidence showed that there is no relationship between renal sympathetic-nerve ablation procedure and reduction of blood pressure. However, as there is still some methodological flaw on the literature, we recommend doing another study that may find the appropriate results.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Resistant hypertension, case based approach to diagnosis and management: case report

Background: Resistant hypertension is defined when the blood pressure remains elevated above the therapeutic target levels despite the use of three antihypertensive agents including calcium channel blocker (CCB), renin-angiotensin system (RAS) blocker and a diuretic. These drugs should be used at maximally tolerated doses and white coat effect and non-adherence should also be excluded. In this ...

متن کامل

Drug-resistant Hypertension: Is Renal Sympathetic Denervation the Answer?

Introduction: Sympathetic overactivity is thought to be a major contributor to the pathogenesis and progression of human hypertension [1, 2]. In particular, renal sympathetic activation results in renal vasoconstriction, increased renin secretion, and enhanced sodium and water reabsorption, all of which contribute to the development of hypertension [3]. Despite this mechanistic understanding, a...

متن کامل

Fibrinolysis of pulmonary emboli--steer closer to Scylla.

n engl j med 370;15 nejm.org april 10, 2014 1457 2. Messerli FH, Bangalore S. Treatment-resistant hypertension: another Cinderella story. Eur Heart J 2013;34:1175-7. 3. Radio waves to kidneys lower persistent high blood pressure. Press release of the American Heart Association, Dallas, December 17, 2012. 4. Krum H, Schlaich M, Whitbourn R, et al. Catheter-based renal sympathetic denervation for...

متن کامل

Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study.

Renal denervation (RDN) is a promising novel treatment for resistant hypertension. Effectiveness of treatment is, however, highly variable and unpredictable. Incomplete denervation of the renal nerves is a plausible explanation for the variable blood pressure lowering effect of RDN. Here, we present for the first time a histopathological evaluation of the effects of RDN on perivascular nerves o...

متن کامل

Joint UK societies’ 2014 consensus statement on renal denervation for resistant hypertension

Resistant hypertension continues to pose a major challenge to clinicians worldwide and has serious implications for patients who are at increased risk of cardiovascular morbidity and mortality with this diagnosis. Pharmacological therapy for resistant hypertension follows guidelines-based regimens although there is surprisingly scant evidence for beneficial outcomes using additional drug treatm...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Acta medica Indonesiana

دوره 46 4  شماره 

صفحات  -

تاریخ انتشار 2014